Novel immunogenic lipopeptides comprising t-helper lymphocyte epitopes and cytotoxic t lymphocytes (ctl), and methods for their production and use

摘要

"NEW IMMUNOGENIC LIPOPEPTIDES UNDERSTANDING T-HELPER LYMPHOCYTE AND CYTOTOXIC LYMPHOCYTE (CTL) EPYTEMS AND METHODS FOR THEIR PRODUCTION AND USE". The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear Thelper and CTL epitopes, and methods for their production and use in generating primary and secondary immune responses, and for vaccinating animals against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side chain group of an internal lysine or lysine analog, preferably to the terminal side chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.