A composition and method for screening anti-malarial drug by using the active form of recombinant calpain in Plasmodium falciparum

摘要

PURPOSE: A composition for screening an anti-malaria drug containing calpain of malaria protozoa is provided to apply to develop an agent for preventing and treating malaria. CONSTITUTION: A composition for screening anti-malaria drug contains a calpain gene of P. falciparum. The calpain gene contains a nucleotide of sequence number 3 or base sequence having 90% or more homology with the nucleotide. A composition for screening the anti-malaria drug contains a protein expressed from the calpain gene. The calpain protein has an amino acid sequence of sequence number 4 or amino acid sequence having 90% or more homology with the amino acid. The anti-malaria drug is screened using the composition as a target material.