ICG Doped Silica Nanoparticles for Biological Imaging and Production Method Thereof

摘要

invention ICG (indocyanine green) doped (doped) silica nanoparticles and its manufacturing method in relates, more particularly, for biological imaging the near-infrared rays, which can be used as the nano-probe fluorescence, PEI (polyethylenimine), aminopropyl trimethoxysilane, and bovine serum albumin conjugated with positively charged molecules ICG-doped silica nanoparticles and having a, such as, the step of bonding the core of positively charged molecules ICG; And to a positive charge to the molecule and the conjugated molecule has a positive charge, including the step of incorporating into the silica nanoparticles conjugated to ICG ICG-doped silica nanoparticles in the production process. ICG-doped silica nanoparticles synthesized by the method of the present invention various methods are possible as well as a low leakage for the scaling transformation in easily and surface nano-level, low toxicity, low bleaching, and in vitro and in vivo imaging fully applicable high sensitivity, and has the advantage of having a continuous stability.