PAI-1 PRODUCT INHIBITOR

摘要

1. A method of inhibiting the production of PAI-1, comprising a step providing for the effect of a compound represented by the following general formula (I) or a salt of said compound on a cell producing PAI-1. ! [Formula 1] ! ! where R1 is a hydrogen atom, an alkylcarbonyl group or a 4- (morpholinyl) carbonyl group; ! D means a benzene cycle or a benzene cycle containing one or more groups selected from the group consisting of: a halogen atom, a nitro group, a cyano group, an alkyl group, an alkoxyiminoalkyl group, a benzyloxyiminoalkyl group, a phenylalkenyl group, a phenylalkynyl group, a trimethylsilylalkyl group, a phenyl group, halogenated alkyl group, pyrrolyl group, alkylpyrrolyl group, thienyl group, alkylthienyl group, alkylthiazolyl group, pyridyl group, and an alkyl pyridyl group, an alkyl carbonyl group, an alkoxycarbonyl group, a pyrrolylsulfonyl group, a (4-nitrophenyl) diazenyl group and a hydroxyl group; and! E means a phenyl group substituted by one or more groups selected from the group consisting of: a halogen atom, a halogenated alkyl group, a phenyl group, an alkyl group, a halogenated alkoxy group, a phenylalkyl group, an alkoxy group, a cyclohexyl group, a phenylalkoxy-halogen group, alkylsulfonyl group, ethynyl group, benzoyl group, alkylsulfonyl group, alkylsulfonyl group, morpholino group, alkyl furyl g uppu, alkylcarbonyl group, 1- (5-phenyl) -3- (halo