PREVENTION AND TREATMENT OF MIDDLE EAR OTITIS

摘要

1. Composition for the prevention or treatment of otitis media, containing IgA obtained from mature cow's milk and having specificity for at least one of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. ! 2. The composition according to claim 1, in which IgA is specific to all of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. ! 3. The composition according to claim 1 or 2, which is a nutritional composition. ! 4. The composition of claim 1 or 2, which is a milk (infant) mixture, an improved mixture or growing-up milk. ! 5. The composition according to claim 4, which contains from 3 to 150 μg IgA per gram of composition based on dry weight. ! 6. The composition of claim 1 or 2, which is an additive and which contains from 2500 to 30000 μg of IgA per daily dose. ! 7. The composition of claim 3, which is an additive and which contains from 2500 to 30000 μg of IgA per daily dose. ! 8. The use of the composition according to claim 1 or 2 in the manufacture of a medicament or therapeutic nutritional composition for the prevention or treatment of otitis media. ! 9. Mature cow milk having an IgA concentration specific for at least one of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, at least 1.5 μg / ml. ! 10. The mature cow milk of claim 9, having a concentration of said IgA of at least 2.5 μg / ml. ! 11. The mature cow milk of claim 9, which has a concentration of IgA specific to all three of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, is at least 10 μg / ml. ! 12. The mature cow milk of claim 11, which has a concentration of IgA specific to all three of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, is at least 12 μg / ml. ! 13. The serum fraction obtained from mature cow milk according to �