METHODS OF TREATING DISORDERS WITH THE APPLICATION OF THE NR2B-SELECTIVE ANTAGONIST OF NMDA RECEPTORS

摘要

1. A method of treating, preventing or alleviating the progress of a disease or condition by inhibiting NMDA receptors containing an NR2B subunit, comprising administering to a patient in need of such treatment a total daily dose of from about 2 to about 50 mg of the compound of formula (I)! ! or a pharmaceutically acceptable salt thereof. ! 2. The method according to claim 1, where the disease or condition is a cognitive disorder, neurodegenerative disease, pain, depression, attention deficit hyperactivity disorder or dependence. ! 3. The method according to claim 2, where the neurodegenerative disease is Alzheimer's disease or Parkinson's disease. ! 4. The method according to claim 2, where the pain is a chronic or acute pain. ! 5. The method according to claim 2 or 4, where the pain is a neuropathic pain or postoperative pain. ! 6. The use of the compounds of formula (I)! ! or a pharmaceutically acceptable salt thereof for treating, preventing, or alleviating the occurrence of a cognitive disorder, neurodegenerative disease, pain, depression, attention deficit hyperactivity disorder or dependence, wherein the total daily dose of the compound is from about 2 to about 50 mg. ! 7. The use according to claim 6, where the neurodegenerative disease is Alzheimer's disease or Parkinson's disease. ! 8. The use according to claim 6, where the pain is a chronic or acute pain. ! 9. The use according to claim 6 or 8, where the pain is a neuropathic pain or postoperative pain. !ten. The use of the compounds of formula (I)! ! or its pharmaceutically acceptable salt for the treatment, prevention