APPLICATIONS OF CYTOKINES OF THE IL-22, IL-17 AND IL-1 FAMILIES IN AUTOIMMUNE DISEASES

摘要

1. A method for detecting an inflammatory disorder, comprising determining the positive regulation of at least one of: (a) at least one isoform of IL-1 and (b) IL-1Rrp2 in a patient, where at least one isoform of IL-1 is IL -1F6, IL-1F8 or IL-1F9. ! 2. The method of claim 1, wherein the inflammatory disorder is psoriasis, lupus, or arthritis. ! 3. The method according to claim 1, where the positive regulation of at least one of: (a) at least one isoform of IL-1 and (b) IL-1Rrp2 is determined by measuring mRNA levels. ! 4. The method according to claim 1, where the positive regulation of at least one of: (a) at least one isoform of IL-1 and (b) IL-1Rrp2 is determined by measuring protein levels. ! 5. The method according to claim 1, where the determination of the positive regulation of at least two of: (a) at least one isoform of IL-1 and (b) IL-1Rrp2 is carried out by measuring protein levels of at least one of: (a) at least one isoform of IL-1 and (b) IL-1Rrp2 and by measuring mRNA levels of at least one of: (a) at least one isoform of IL-1 and (b) IL-1Rrp2. ! 6. A method of treating an IL-22 associated disorder, comprising administering at least one inhibitor of at least one of IL-1F6, IL-1F8, and IL-1F9 to a patient with said IL-22 associated disorder. ! 7. The method according to claim 6, where at least one inhibitor is an anti-IL-1F6 antibody. ! 8. The method according to claim 6, where at least one inhibitor is an anti-IL-1F8 antibody. ! 9. The method according to claim 6, where at least one inhibitor is an anti-IL-1F9 antibody. ! 10. The method of claim 6, wherein the at least one inhibitor is an anti-IL-1Rrp2 antibody. ! 11. The method according to any one of claims 6 to 10, where IL-22 is associated