REPRODUCTION INHIBITOR OF INFLUENZA A VIRUS BASED ON EXTRACTS OF BASIDIOMYCETES FUNGUS LAETIPORUS SULPHUREUS

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: inhibitor of influenza A virus reproduction represents water extract of basidial Laetiporus sulphureus, obtained by extraction of crushed fungus biomass with water at ratio 1:1 or 1:2 with further removal of insoluble deposit from extract. Claimed inhibitor demonstrates high inhibiting effect with respect to influenza A virus. Index of virus neutralisation in culture of MDCK cells constitutes 2.5-7 lg. Titres of influenza A virus in homogenates of light infected mice constitute (4.67±0.6)-(6.0±0.57) lgEID₅₀/ml±I₉₅.;EFFECT: high inhibitor activity.;3 cl, 6 tbl, 4 ex