APPLICATION OF ALLOPURINOL FOR TREATING PALMOPLANTAR ERYTHRODYSESTHESIA

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: what is offered is application of allopurinol or its pharmaceutically acceptable salt for treating or preventing palmoplantar erythrodysesthesia (PPE) induced by fluoropyrimidine chemotherapy, a related method of treating and a pharmaceutical composition for skin application of the same purpose, and the composition does not contain methyl sulphonyl methane or cetomacrogol.;EFFECT: relief, and in 66% of patients - delitescence of PPE symptoms in the absence of toxic effects on allopurinol and compliance of the patients is shown.;12 cl, 3 tbl