Incidence of Urolithiasis in Dogs Naturally Infected by Leishmania infantum Treated with Allopurinol

摘要

Allopurinol has been increasingly used for the treatment of canine visceral Leishmaniasis (CVL). The formation of urinary xanthine urolithiasis has been related as a possible complication of allopurinol therapy.The aim of this study is to evaluate the incidence of urolithiasis in dogs naturally infected byL. infantum.193 dogs naturally infected by L. infantum, were included in this study.The survey was conducted through a retrospective evaluation of medical records and laboratory tests from January 2015 to July 2017. The inclusion criteria of the dogs in the study were to have either positive ELISA, RIFI above 1:160 or positive reactionon SNAP Leishmania IDEXX. The medical record should contain complete anamnesis, detailing type of feeding, medications administered and complementary exams of abdominal ultrasound and routine urine analysis.