SYSTEMS AND METHODS OF ESTIMATING GASA TRANSFER IN LUNGS WITH APPLICATION OF MRT WITH HYPERPOLARISED ¹²⁹Xe

摘要

FIELD: medicine.;SUBSTANCE: invention relates to NMR-spectroscopy and magnetic-resonance tomography. Method of estimation lies in transmission of visualising sequence of RF MRT-pulses of excitation, configures for excitation of hyperpolarised ¹²⁹Xe of dissolved phase in the area of lung gas exchange in the subject and generation of three-dimensional MRT-image of ¹²⁹Xe area of lung gas exchange, associated both with compartment of red blood cells (RBC) and with compartment of the barrier. Visualising sequence of RF pulses is carried out with application of pulse with selected frequency, which excites resonances of both RBC compartment of polarised ¹²⁹Xe of dissolved phase and of barrier compartment, but not the resonance of ¹²⁹Xe gas phase for accumulation of RBC signal with 90 degree difference of phases with barrier compartment signal. System of MRT-scanner contains MRT-scanner with MRT-receiver with a set of channels, including the first channel, formed with possibility to receive data of signal of ¹²⁹Xe REBC of RBC compartment of patient's lung, and the second channel, formed with possibility to receive data of signal of ¹²⁹Xe of patient's lung barrier compartment. System of data processing for generation of MRT-images of ¹²⁹Xe contains computer-readable medium of data storage, which has computer-readable code of programme, which contains codes of generation of RF pulses of excitation, obtaining MRT-signal of dissolved phase ¹²⁹Xe, associated with reds blood cells in the area of lung gas exchange, obtaining MRT-signal of dissolved phase ¹²⁹Xe, associated with alveolar-capillary barrier in lung, generation of 3D MRT-image, attenuation of signal on image being connected with reduced ability to alveolar-capillary transfer.;EFFECT: application of invention makes it possible to increase tomography self-descriptiveness due to possibility to distinguish between two compartments: barrier gas/blood.;20 cl, 14 dwg