CLEAVED PARTICLES FOR PRESENTATION OF FOREIGN MOLECULES, FIRST OF ALL FOR USAGE IN VACCINES, AND METHOD FOR MAKING THEM

摘要

FIELD: medicine.;SUBSTANCE: there are disclosed substances representing a cleaved carrier and containing in the form of independent polypeptides of coreN- and coreC-domains of core proteins of hepatitis B virus and at least one foreign molecule whereto the immune response is required to be induced. According to the invention, the foreign molecule, first of all a heterological foreign amino acid sequence is fused either with the C-terminal of the coreN-domain, or with the N-terminal of the coreC-domain, and the core protein possesses an ability to form capsid-like particles. There are also described a related method for making and a diagnostic and a therapeutic agent.;EFFECT: effective applicability in medicine.;16 cl, 9 dwg, 15 ex