DNA COMPOSITION FOR INDUCING IMMUNE RESPONSE ON TUMOUR-ASSOCIATED MACROPHAGUES

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to medicine and concerns a pharmaceutical composition for inducing an immune response on tumour-associated macrophagues containing a mini-gene DNA construct which codes a polypeptide in a pharmaceutically acceptable carrier wherein the polypeptide contains three immunogenic legumain fragments bonded together with linker peptides, and wherein each linker peptide consists of the AAA or AAY sequence.;EFFECT: invention provides effective control of breast carcinoma, non-small-cell lung cancer and colorectal carcinoma.;8 cl, 2 ex, 26 dwg