POLYPEPTIDE ABLE TO BLOCK CELL SURFACE RECEPTOR CCR5 AND/OR TO INDUCE CCR5 INTERNALISATION AND/OR INHIBITORY REGULATION IN TARGET CELL, NUCLEIC ACID CODING IT, HOST CELL, USE (VERSION), PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING OR PREVENTING HIV INFECTION IN PATIENT (VERSIONS)

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to biotechnology, more specifically preparing cytokine derivatives and may be used in medicine. A recombinant method is used to produce a polypeptide containing an N-terminal portion and a C-terminal portion wherein said N-terminal portion involves a characteristic sequence QGP[P or L], and an amino acid sequence of said C-terminal portion is at least 70% identical to SEQ ID NO:1. The produced polypeptide, the nucleic acid coding it and the host cell expressing it are used in treating or preventing HIV infection, acquired immunodeficiency syndrome (AIDS) or HIV transmission.;EFFECT: invention enables producing the polypeptide able to block the cell surface receptor CCR5 and/or to induce CCR5 internalisation and/or inhibitory regulation in the host cell.;19 cl, 4 dwg, 5 tbl, 6 ex