METHOD FOR EXPERIMENTAL AZYTHROMYCIN CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER IN ADMA-LIKE GESTOSIS MODELS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine. A method involves a reproducible ADMA-like gestosis model in pregnant female rats Wistar by the daily 7-day intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg. This daily 7-day intraperitoneal introduction is combined with the intragastric introduction of the antibacterial preparation Azythromycin 30 mg/kg/day of the group of macrolides.;EFFECT: method is effective for correction of placental microcirculation disorder.;1 ex