SIONERGISTIC PHARMACEUTICAL COMBINATION FOR PAIN TREATMENT (VERSIONS)

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: claimed are: application of combination of flurpirtine and tramadol or their physiologically acceptable salts with weight ratio of flurpirtine to tramadol from 10:1 to 1:14 for pain treatment and application of the same combination for obtaining mediaction for peroral, rectal, intravenous, transcutaneous, or subcutaneous or intracutaneous introduction for pain treatment.;EFFECT: demonstrated is increased efficiency (synergism) of combination in pain treatment and unexpected "anti-vomiting" effect of flurpirtine in combination with vomiting-inducing high dose of tramadol; as well as introduction of combination results in reduction of such side effects as cramps, increased muscle tone and vomiting.;13 cl, 6 tbl