Method for the diagnosis of familial adenomatous polyposis (FAP)

摘要

A method for diagnosing familial adenomatous polyposis (FAP), characterized by the steps of: determining the expression of at least one protein selected from the group consisting of RNF115, HSPA8, HSPD1, ASTN2, KRT9, KRT10, UQCRC1, CCT5, NDUFS1, ACTB, LMNA, ACY1, RUVBL1, CSTF2T, TIGD5, ECH1, ALDH2 and KRT18 in a tissue sample of a first individual; and comparing the expression of the at least one protein in the tissue sample of the first individual with the expression of the at least one protein in a tissue sample of a healthy second individual and / or a third individual with sporadic colorectal carcinoma, wherein the presence of increased expression of the at least one protein in the tissue sample of the first individual indicates the presence of familial adenomatous polyposis (FAP).