A topical nanoparticles - a vaccine for the immune stimulation of the dendritic cells in the skin

摘要

The present invention relates to novel topical vaccine which, with the aid of a particles - based carrier system in a targeted manner the dendritic cells of the skin addressing and consequently an effective prophylactic and / or therapeutic t - cell - mediated immunity induce.The present invention also relates to the composition of such a vaccine of antigen - determinants for cytotoxic effector - t - cells and helper, - t - cells, as well as the use of synthetic analogs of bacterial lipopeptides as tlr - based adjuvants for the amplification of the specific immune response.A combination of the vaccine components is of nanoscale particles immobilized, after application on the skin by this in an active transport process in the hair follicles and there deposited temporarily. The under the physiological conditions in the hair follicles released active ingredients to diffuse the target structures in the skin, stimulate the cell surface of a flat receptors of the dendritic cells and induce a selective t - cellular immune response.The new topical nanoparticles - vaccine and the formulations thereof are suitable, on the one hand, for the prevention and, on the other hand, for the treatment of diseases such as infections, cancer, autoimmune diseases, chronic inflammations and allergies in humans and animals.