N- 3-Fluoro-4-({6- (methyloxy) -7-(3-morpholin-4-ylpropyl) oxy -quinolin-4-yl} oxy) phenyl -N '-(4- Hydrated crystalline form of fluorophenyl) cyclopropane-1,1-dicarbosamide

摘要

This invention relates crystalline hydrates of N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, Compound (I). The invention provides methods for treatment of cancer by exploiting the modulation of protein kinase activity. The invention also provides pharmaceutical compositions containing a crystalline hydrate of Compound (I) and a pharmaceutically acceptable excipient.