p62:Nrf2 GENE DOUBLE KNOCKOUT MOUSE AS SPONTANEOUSLY DEVELOPING MODEL OF NONALCOHOLIC FATTY LIVER DISEASE AND LIVER TUMOR, AND METHOD FOR USING THE MOUSE

摘要

PROBLEM TO BE SOLVED: To provide a model animal useful for developing a therapeutic agent of NASH.SOLUTION: There is provided a knockout non-human animal which is deleted whole or part of p62 gene and deleted whole or part of Nrf2 gene, or one part of the knockout non-human animal.