DIAGNOSIS, PROGNOSIS AND MONITORING OF DISEASE PROGRESSION OF SYSTEMIC LUPUS ERYTHEMATOSUS THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS

摘要

PROBLEM TO BE SOLVED: To provide compositions, arrays and methods for the early detection and consistent determination of SLE using modular analysis of gene expression data.SOLUTION: A method for determining whether an individual has systemic lupus erythematosus (SLE), comprises steps of: obtaining the transcriptome of a patient; scoring the transcriptome based on one or more transcriptional modules; and determining the patient's disease or condition based on the presence, absence or level of expression of genes within the transcriptome in the one or more transcriptional modules that are indicative of SLE. The invention relates to a system and method for the diagnosis, prognosis and monitoring of SLE disease progression before, during and after treatment is provided.