HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR (HB-EGF) PRODUCTION PROMOTER

摘要

PROBLEM TO BE SOLVED: To provide an HB-EGF production promoter, a turn-over promoter for epidermis, a melanin evacuant or a skin whitening agent, or an external preparation composition containing one or more of the above agents, which is safe and has an excellent effect equivalent to or higher than a retinoic acid, while preventing problems relating to safeness such as a side effect of stimulation on a skin or the like caused by continuous use.;SOLUTION: The HB-EGF production promoter contains, as an active ingredient, an extract of cat's claw (Uncaria tomentosa, Rubiaceae family) bark that has an HB-EGF production promoting effect and an epidermal keratinocyte proliferation promoting effect, and thereby, the HB-EGF production promoter can effectively inhibit or improve pigmentation in a skin such as speckles, freckles, somberness and melanotic skin due to exposure to UV rays. Further, the promoter develops an anti-aging effect or an effect of keeping good skin conditions for preventing somberness or aged skin conditions that are caused by decrease in a proliferation function of keratinocyte due to aging, causing delay in the turn-over of epidermis, and has an effect of maintaining a healthy skin.;COPYRIGHT: (C)2013,JPO&INPIT