Method for determining the presence or absence of down-regulation of signal transduction pathways via ErbB2, a method for assisting judgment of necessity of treatment with anticancer agents and signal transduction inhibitors

摘要

It is intended to provide a signaling inhibitor for use therein and methods for inhibiting the activation of a signal transduction pathway mediated ErbB2 in human cells. It is possible that the polypeptide comprising one, to inhibit the activation of the signal transduction pathway of least ERK2 binding domain or the PTB domain of human FRS2β. Can be introduced into cells to itself, introducing into the cells a nucleic acid encoding the polypeptide, the polypeptide may be used to express the polypeptide in the cell. For example, nucleic acid or polypeptide such, can be used as a signal transduction inhibitor. Also, ErbB2, since it is associated with development of cancer, for example, the signal transduction inhibitor is also useful as an anticancer agent.