State of the sick condition in real time the observation possible model animal gene construction ones and its use null reporter gene which make

摘要

The present invention aims without damaging the animal, the adverse condition functionally stage before reaching up pathology or condition in animal tissues, is to provide a technique for real-time observation in particular. This object is achieved by a gene construct with ODD domain (oxygen dependent degradation domain) upstream of a reporter gene, and is integrated under the control of a hypoxia responsive promoter reporter gene.