The non indicator manner regarding the hERG kalium ion channel

摘要

Those where it is disclosed here, using the non indicator (Label-free) biosensor (biosensor), are the manner which sorts the ion channel modulation medicine (modulator) of the human delay rectification Characteristic kalium ion channel gene (hERG). As for being disclosed here, using the resonance guided wave path diffraction grating die (RWG) biosensor of the non indicator, it is to make the pattern of the DMR signal of the hERG modulation medicine in the cell stocks (natural cell stocks intrinsic revealing hERG, hERG natural cell stocks which are not included, and artificial cell stocks which stably reveal hERG) of 3 types clear, furthermore, the modulation index to which the modulation medicine numerator for the marker/the hERG activator (activator) operation on the panel of the cell corresponds, with the known activator in the hERG revelation sex cell stocks of especially above-mentioned twoIt is to make the DMR signal of certain marotokishin (mallotoxin) clear.