Therapeutic drug delivery systems for topical application of therapeutic agents to biological conduits, devices, and methods

摘要

Systems for topical application of therapeutic agents of biological conduit, devices, and the present invention provides a method. It has an elongate rotatable drive shaft with a flexible having a lumen, has application at least one hole and is attached through it, one embodiment is in communication with the operator control actuator and therapeutic delivery sheath It is equipped with the eccentric enlarged polishing head, a rotary atherectomy device. Then, the therapeutic agent, may be sprayed radially outwardly from the application of the eccentric hole on the polishing head and the high-speed rotation of the head / or after. Another embodiment comprises a section of the polishing head for holding a therapeutic agent for release during high-speed rotation. In each case, the therapeutic agent is delivered in a radial force is due to the high speed rotation of the eccentric orbital polishing head, is driven into the duct wall treatment agent.