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Lipopeptide building block having coiled-coil structure, lipopeptide helix bundle, synthetic virus-like particle, and pharmaceutical preparation
Lipopeptide building block having coiled-coil structure, lipopeptide helix bundle, synthetic virus-like particle, and pharmaceutical preparation
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机译:具有卷曲螺旋结构的脂肽结构单元,脂肽螺旋束,合成病毒样颗粒和药物制剂
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摘要
The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.
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