Molecular design of functional RNA- protein complex

摘要

PPROBLEM TO BE SOLVED: To provide a method to immobilize arbitrary proteins on RNA bases without damaging functional structures of bases such as proteins and RNA. PSOLUTION: An RNA-protein complex 1 comprises a base RNA2 having base sequences (boxB sequence, RRE sequence) 23, 24 derived from an RNA-protein complex 1 interaction motif; and fusion proteins 3, 4 containing amino acid sequences 31, 41 derived from RNA-protein complex interaction motif binding to protein (N peptides, Rev proteins) 30, 40 and the base sequences nonconvalently and specifically. PCOPYRIGHT: (C)2009,JPO&INPIT