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Method for producing virus-removed plasma protein composition by porous membrane treatment, virus-removed plasma protein composition, and virus removal method
Method for producing virus-removed plasma protein composition by porous membrane treatment, virus-removed plasma protein composition, and virus removal method
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机译:通过多孔膜处理生产除病毒血浆蛋白组合物的方法,除病毒血浆蛋白组合物和除病毒方法
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摘要
Contaminant viruses can be efficiently removed almost without losing the activity of protein by subjecting a plasma protein composition having a high risk of viral contamination to a treatment with a porous membrane having a pore size greater than a single-particle size of the virus, particularly by subjecting a plasma protein composition to a fractionation treatment by precipitation, before the porous membrane treatment. Particularly, a fibrinogen composition substantially free of non-enveloped viruses, Parvovirus among others, can be provided. By the application of the present invention, a safe plasma protein preparation free of viruses can be conveniently provided.
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