Detection marker for low-dose exposure in stem cells, and method for estimating or detecting low-dose exposure level in stem cells using the marker

摘要

PROBLEM TO BE SOLVED: To provide a method for deducing or detecting influence on stem cells by radiation at low doses of about several mGy levels, to provide a method for predicting the induction of the stem cells to apoptosis that stems from such a low-dose exposure, and to provide a method for screening a substance inhibiting a low-dose radiation inductive cell apoptosis and predicting induction to apoptosis.;SOLUTION: The method for determining or detecting the low-dose exposure to a stem cells comprises determining the increase of the expression level of PPP1CA, BAD and/or BCL-XL gene in the stem cells. The method for predicting the induction of the stem cells to apoptosis stemming from such a low-dose exposure is also provided.;COPYRIGHT: (C)2008,JPO&INPIT