Its high-sensitivity detection methods with the production of intestinal inflammation-induced cause molecules by highly pathogenic oral bacteria

摘要

The object of the present invention is to construct a system of identifying the causative factors that lead to deterioration of inflammatory gastrointestinal disease, can be identified quickly and easily patients at risk of deterioration of inflammatory gastrointestinal disease. By CBP and / or comprises detecting a CBP is a collagen-binding protein and PA / or the protein antigen of the oral bacteria in the sample, PA is not detected is detected, the present invention may be useful for the digestion How to make a determination of the risk of worsening of inflammatory gastrointestinal disease in a subject and / or screening of the target risk of worsening of inflammatory gastrointestinal disease and / or detection of oral bacteria that causes the deterioration of the vessel disease is high, and as kits and detection reagents for use in such methods.