The protein where the new gene, and the aforementioned gene of the hansenuraporimoruhua beginning which dolichol phosphate mannose dependence 1,3 mannoshirutoransuhueraze the code is done the amino acid array which is displayed with the rearrangement glycoprotein production mannered null

摘要

This invention heredity operates the enzyme which participates in sugar chain formation engineering, regards the method of producing the human type glycoprotein which saccharification decreases making use of hansenuraporimoruhuashisutemu. From concretely, this invention identifies the dolichol phosphate mannose dependence 1,3 mannoshirutoransuhueraze gene of hansenuraporimoruhua, the description above deficiency point to the gene which is identified, to produce the hansenuraporimoruhua variant which produces the glycoprotein which saccharification decreases, regards the method of producing the glycoprotein which has the human type sugar chain due to the various operations of the aforementioned variant.