Method for producing a chimeric rat using rat embryonic stem cells

摘要

The method for preparing a chimeric rat and chimeric embryos, the present invention provides a method comprising the step of contacting the host embryo in the presence of ES cell differentiation inhibitor rat pluripotent stem cells. Contacting in the presence of ES cell differentiation inhibiting agent, the host embryo after fertilization, which is taken from rats (a) a female, and a rat pluripotent stem cells, the method, (b) a rat pluripotent stem cells comprising the step of culturing the host embryos is brought into contact with, to form a chimeric embryo.