Pharmaceutical composition comprising core factor related to proliferation and differentiation of central nerve cell

摘要

In order to provide a new factor that induces the proliferation and differentiation of neural stem cells, 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or neural progenitor cell expressing CRBN A pharmaceutical composition characterized by containing, a method of administering this pharmaceutical composition to a non-human animal, and inducing proliferation and differentiation into neural stem cells or neural progenitor cells of the non-human animal, and CRBN The present invention provides a screening method for a therapeutic agent for cerebral cortical disease or surgical damage of cerebral cortex using the method.