Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation

摘要

Compositions and uses of mGluR₅ antagonists for the treatment and inhibition of amyloid precursor protein (APP), Aβ protein, and APP proteolytic products in Alzheimer's disease, Fragile X Syndrome, autism, and Down's Syndrome are provided. The invention provides methods for diagnosing Fragile X Syndrome via the assessment of Aβ_1-42 levels in blood plasma.