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MICROFLUIDIC ASSAY IN IDEALIZED MICROVASCULAR NETWORK FOR CHARACTERIZATION OF LEUKOCYTE ADHESION CASCADE
MICROFLUIDIC ASSAY IN IDEALIZED MICROVASCULAR NETWORK FOR CHARACTERIZATION OF LEUKOCYTE ADHESION CASCADE
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机译:用于表征白细胞粘附级联的理想化微血管网络中的微流体分析
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摘要
Methods of assaying the leukocyte adhesion cascade (LAC) and monitoring leukocyte rolling, adhesion, and/or migration can be implemented with an apparatus that includes an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space). The methods of assaying the LAC can be implemented with means for quantifying modulation of the leukocyte adhesion cascade. Methods of assaying the LAC can be implemented with the device and one or more active agents to monitor leukocyte rolling, adhesion, and/or migration in the presence of absence of the active agent. Migration can be through the idealized flow channels, through the porous wall, and/or into the tissue space.
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