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VECTORS AND METHODS FOR LONG-TERM IMMUNE EVASION TO PROLONG TRANPLANT VIABILITY
VECTORS AND METHODS FOR LONG-TERM IMMUNE EVASION TO PROLONG TRANPLANT VIABILITY
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机译:长期免疫以延长移植物存活率的矢量和方法
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摘要
A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
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