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METHODS AND COMPOSITIONS FOR TREATMENT OF TOX-3 AND TFF-1 MEDIATED CANCER PATHOGENESIS
METHODS AND COMPOSITIONS FOR TREATMENT OF TOX-3 AND TFF-1 MEDIATED CANCER PATHOGENESIS
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机译:治疗Tox-3和TFF-1介导的癌症的方法和组合物
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摘要
The present invention relates to biomarkers useful for the diagnosis, prognosis and treatment of cancer. In different embodiments, the invention relates to TOX3 and related biomarkers, such as TFF1, TFF3, AGR2, SCUBE2, CEACAM6, TSPAN1 or CXCR4. TOX3 and these related biomarkers are also useful for the characterization of different breast cancer disease subtypes. Also described herein are inventive compositions and methods drawn to the use of anti-TOX3 antibodies, inducible TOX3 transgenic animal models, TOX3 nucleic acids, peptides, and small molecules for detection and modulation of TOX3 function and/or expression.
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