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Fascile synthesis of biocompatible polymer capsule nanoparticles for drug encapsulation
Fascile synthesis of biocompatible polymer capsule nanoparticles for drug encapsulation
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机译:用于药物包封的生物相容性聚合物胶囊纳米粒子的简便合成
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摘要
The present invention relates to a method for preparing a capsule nanoparticle used in encapsulating hydrophobic medicines, comprising the following steps: (A) providing a biocompatible polymer and an organic solution containing a hydrophobic medicine; (B) stirring the organic solution at 3-10° C., and titrating with an alcohol solution, so as to make the biocompatible polymer encapsulate hydrophobic medicine to form a capsule nanoparticle; (C) ultrasonic vibrating the capsule nanoparticle at 3-10° C.; (D) filtering the capsule nanoparticle to an average size controllable in the range of 60-450 nm; and (E) lyophilizing the encapsulated particles.
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