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INFECTIOUS HEPATITIS C VIRUS-HIGH PRODUCING HCV VARIANTS AND USE THEREOF
INFECTIOUS HEPATITIS C VIRUS-HIGH PRODUCING HCV VARIANTS AND USE THEREOF
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机译:感染性丙型肝炎病毒生产HCV变异株及其用途
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摘要
An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing.
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机译:本发明的目的是提供一种在细胞培养系统中具有高生产病毒能力的HCV株。本发明提供了一种编码具有一个或多个氨基酸取代的丙型肝炎病毒JFH1菌株的多蛋白前体的核酸,其中该多蛋白前体至少包含862位的谷氨酰胺被精氨酸取代,这是参照氨基酸序列确定的如序列表中SEQ ID NO:2所示。
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