A grid-based data clustering method performed by a computer system includes a setup step, a dividing step, a categorizing step and an expanding/clustering step. The setup step sets a grid quantity and a threshold value. The dividing step divides a space containing a data set having a plurality of data points into a two-dimensional matrix. The matrix has a plurality of grids G(i,j) comprising a plurality of target sequences and a plurality of non-target sequences interlaced with the plurality of target sequences. The indices “i” and “j” of each grid G(i,j) represents the coordinate thereof. The categorizing step determines whether each of the grids is valid based on the threshold value. The expanding/clustering step respectively retrieves each of the grids of the target sequences, performs an expansion operation on each of the grids retrieved and clusters the plurality grids G(i,j).
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