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Therapeutic Uses of Monoclonal Antibodies to the Angiotensin-II Type-1 Receptor

机译：血管紧张素II 1型受体单克隆抗体的治疗用途

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The use of monoclonal antibodies to the angiotensin-II type-I receptor is provided for the treatment of cancer and vascular smooth muscle cell proliferation. Specifically, use is provided of a monoclonal antibody or a fragment thereof to a peptide comprising the N-terminal portion of the angiotensin-II type-1 receptor defined by the sequence; <TableGroup align="left" colSep="0" cols="1" rowSep="0"> <Colspec align="right" colName="1" colWidth="217pt"/> <Tbody valign="top"> <Row> <entry>(SEQ ID NO: 1)</entry> </Row> <Row> <entry>MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFG</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table>in the preparation of a medicament for the treatment of cancer or in the preparation of a medicament for the treatment of vascular smooth muscle (VSM) cell proliferation. </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>提供抗血管紧张素-II-I型受体的单克隆抗体用于治疗癌症和血管平滑肌细胞增殖。具体地，提供针对包含由该序列定义的血管紧张素-II 1型受体的N-末端部分的肽的单克隆抗体或其片段; <Table id =“ TABLE-US-00001”> <TableFormula> <标题/> <TableGroup align =“ left” colSep =“ 0” cols =“ 1” rowSep =“ 0”> <Colspec align =“ right” colName =“ 1” colWidth =“ 217pt” /> <Tbody valign =“ top”> <行> <entry>（SEQ ID NO：1）</ entry> </ Row> <行> <entry> MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFG </ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table>在制备用于治疗癌症的药物中或在制备用于治疗血管平滑肌（VSM）细胞增殖的药物中。 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33">著录项</h2> <div class="getdents"> <ul> <li> <p><span>公开/公告号</span><span>US2013202604A1</span></p> <p><span>专利类型</span><span></span></p> </li> <li> <p><span>公开/公告日</span><span>2013-08-08</span></p> <p><span>原文格式</span><span>PDF</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">申请/专利权人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=QUEEN MARY & WESTFIELD COLLEGE UNIVERSITY OF LONDON&option=232">QUEEN MARY & WESTFIELD COLLEGE UNIVERSITY OF LONDON;</a><a href="/search.html?doctypes=12_13&sertext=GAVIN PAUL VINSON&option=232">GAVIN PAUL VINSON;</a><a href="/search.html?doctypes=12_13&sertext=JOHN RICHARD PUDDEFOOT&option=232">JOHN RICHARD PUDDEFOOT;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请/专利号</span><span style="width: 250px;">US201313749180</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">发明设计人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=GAVIN PAUL VINSON&option=202">GAVIN PAUL VINSON;</a><a href="/search.html?doctypes=12_13&sertext=JOHN RICHARD PUDDEFOOT&option=202">JOHN RICHARD PUDDEFOOT;</a><a href="/search.html?doctypes=12_13&sertext=STEWART BARKER&option=202">STEWART BARKER;</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请日</span><span>2013-01-24</span></p> </li> <li> <p style="width: 100%;"><span>分类号</span><span style="width: 80%;">A61K39/395;</span> </p> </li> <li> <p style="width: 100%;"><span>国家 </span><span style="width: 93%;">US</span></p> </li> <li><p style="width: 100%;"> <span >入库时间</span> <span>2022-08-21 16:47:54</span></p> </li> </ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity"> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul > <li >专利</li> <li >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120109026153.html">血管紧张素II‑1型机械应力受体感受位点在制备治疗高血压的药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN106540261A </span> <span> . 2017-03-29</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120636929.html">一种血管紧张素II受体1型人免疫源性肽段的应用</a> <b>[P]</b> . <span> 中国专利： CN1896094B 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