THERAPEUTIC USES OF MONOCLONAL ANTIBODIES TO THE ANGIOTENSIN-II TYPE-1 RECEPTOR

摘要

The use of monoclonal antibodies to the angiotensin-II type-I receptor isprovided for the treatment of cancer and vascular smooth muscle cellproliferation. Specifically, use is provided of a monoclonal antibody or afragment thereof to a peptide comprising the N-terminal portion of theangiotensin-II type-1 receptor defined by the sequence MILNSSTEDG IKRIQDDCPKAGRHNYIFVM IPTLYSIIFV VGIFG in the preparation of a medicament for thetreatment of cancer or in the preparation of a medicament for the treatment ofvascular smooth muscle (VSM) cell proliferation.