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Methods of identifying ligands to sour-taste receptors comprising PKD1L3 and PKDPKD2L1
Methods of identifying ligands to sour-taste receptors comprising PKD1L3 and PKDPKD2L1
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机译:鉴定包含PKD1L3和PKDPKD2L1的酸味受体的配体的方法
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摘要
The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
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