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NOVEL DESMIN PHOSPHORYLATION SITES USEFUL IN DIAGNOSIS AND INTERVENTION OF CARDIAC DISEASE
NOVEL DESMIN PHOSPHORYLATION SITES USEFUL IN DIAGNOSIS AND INTERVENTION OF CARDIAC DISEASE
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机译:用于诊断和干预心脏病的新型结蛋白磷酸化位点
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摘要
This invention relates to novel phosphorylation sites in the desmin protein that are associated with the onset of heart failure. The phosphorylation sites, i.e., Ser-27 and Ser-31, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
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