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COMPOSITIONS AND METHODS FOR REMOVAL OR DESTRUCTION OF AMYLOID FIBRIL OR AMYLOID ADHESIN COMPRISING AGGREGATES
COMPOSITIONS AND METHODS FOR REMOVAL OR DESTRUCTION OF AMYLOID FIBRIL OR AMYLOID ADHESIN COMPRISING AGGREGATES
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机译:包含聚集物的淀粉状原纤维或淀粉状adheses的去除或破坏的组合物和方法
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摘要
Methods and compositions for treating biofilms and diseases associated with amyloidosis such as Alzheimer's, Parkinson's and Huntington's disease, and Type 2 diabetes, by destroying amyloid fibrils in a two-step treatment are disclosed. The first step consists of binding to the amyloid fibril an intercalating molecule with a negatively charged group such as Congo red. The second step consists of adding metal ions, such as silver, gold(I), copper(I), palladium or lead ions or metal colloids of silver or gold, which destabilize the amyloid-dye complex. This process results in a disintegration of the fibril into peptide monomers and small aggregates of monomers.
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