Isolated fruit extracts and components along with a method for treating or preventing a disease or condition by providing a fruit extract fraction having a therapeutically effective amount of activity in modulating undesired signal transduction activity useful for reducing the frequency, duration or severity of a disease or condition in a subject. The fruit extracts are preferably derived from a plant of one or more of the genera Fragaria or Rubus. The isolated fruit extracts or compositions provide anti-dysplastic activity and modulate signal transduction activity by inhibiting one or more of AP-1, NFkB, Akt, COX-2, and VEGF.
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