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Interferon alpha sequential regimen for treating cancers

机译:干扰素α序贯疗法治疗癌症

摘要

The present invention relates to a method of treating cancers, especially those showing resistance to classical anti-pro liferative chemotherapy drugs. Further, the invention provides a specific interferon alpha sequential regimen for treating cancers, especially those showing resistance to classical anti-proliferative chemotherapy drugs such as stem cell driven cancers. More specifically, the invention relates to a use of IFN alpha for the preparation of a pharmaceutical formulation for the treatment of cancers wherein the pharmaceutical formulation is to be administered following a sequential administration pattern i.e. an induction period wherein a therapeutically effective amount of IFN alpha is administered, a period during which no IFN alpha is administrated and a chemotherapy period wherein a therapeutically effective amount of a chemotherapeutic agent is administered.
机译:本发明涉及一种治疗癌症的方法,特别是显示出对经典抗增殖化学疗法药物有抗性的那些癌症。此外,本发明提供了一种特异性的干扰素α序贯疗法,用于治疗癌症,尤其是那些显示出对经典抗增殖化学疗法药物如干细胞驱动的癌症具有抗性的癌症。更具体地,本发明涉及IFNα在制备用于治疗癌症的药物制剂中的用途,其中所述药物制剂将按照顺序给药方式即诱导期给药,其中治疗有效量的IFNα为:施用期间,不施用IFNα的时期和其中施用治疗有效量的化学治疗剂的化学疗法时期。

著录项

  • 公开/公告号US8329160B2

    专利类型

  • 公开/公告日2012-12-11

    原文格式PDF

  • 申请/专利权人 ANDREAS TRUMPP;MARIEKE ESSERS;

    申请/专利号US20080664726

  • 发明设计人 ANDREAS TRUMPP;MARIEKE ESSERS;

    申请日2008-06-13

  • 分类号A61K38/21;C07K14/56;

  • 国家 US

  • 入库时间 2022-08-21 16:46:23

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