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METHOD OF MODELING FOR DRUG DESIGN, EVALUATION AND PRESCRIPTION IN THE TREATMENT OF DISEASE
METHOD OF MODELING FOR DRUG DESIGN, EVALUATION AND PRESCRIPTION IN THE TREATMENT OF DISEASE
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机译:疾病治疗中药物设计,评价和处方的建模方法
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摘要
A method implemented on at least one specifically programmed computer to improve the outcome of a drug trial. The method includes (a) generating a parameterized mathematical model of disease and immune response, (b) including in the parameterized mathematical model effects from one or more drugs with time-dependent variables that can change during a therapy, (c) creating a calibrated model using empirical data to aid in determining parameters of the parameterized mathematical model, (d) determining responses of the calibrated model to a series of time-dependent drug therapies, and (e) selecting at least one therapy based on the determined responses of the model.
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