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Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates

机译：制备原卟啉（IX）和合成中间体等原卟啉衍生物的方法

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摘要

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex:; embedded image

in which:R and R′ are as defined in claim 1, comprising:a step of condensation, in an acidic medium, between a dipyrromethane of formula (II):; embedded image

in which R′b is as defined above for (I),and a dipyrromethane of formula (III):; embedded image

in which R″ is as defined in claim 1, and also the compounds of formula (III).

机译：本发明涉及一种制备式（I）的卟啉的方法，该卟啉任选以与碱金属的盐的形式和/或以金属络合物的形式： “嵌入式图像”

其中： R和R'如权利要求 1 包括： < ListItem id =“ ul0002-0003” number =“ 0000”>在酸性介质中，在式（II）的二吡咯甲烷之间进行缩合的步骤： ; 其中R′b如以上对于（I）所定义，和式（III）的二吡咯甲烷： ; 其中R”如权利要求 1 所定义，以及式（III）化合物。 展开▼

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公开/公告号US8420805B2

专利类型

公开/公告日2013-04-16

原文格式PDF

申请/专利权人 PIERRE MARTIN;MARKUS MUELLER;DIRK SPIELVOGEL;DIETMAR FLUBACHER;ANDREAS BOUDIER;
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申请/专利号US201113218149

发明设计人 PIERRE MARTIN;MARKUS MUELLER;DIRK SPIELVOGEL;DIETMAR FLUBACHER;ANDREAS BOUDIER;
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申请日2011-08-25

分类号C07D487/22;

国家 US

入库时间 2022-08-21 16:46:05

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